P in the ear?

[kozi1]

Hi everyone. I'm just curious if anyone is dealing with or has dealt with P
in the ear canal. I have other spots throughout the rest of my body that I
can deal with, but it seems that the P is causing some hearing problems. I'm
to afraid to try any meds in the ear (sideaffects unknown). Any suggestions
would be appreciated.

[URAQT2]

kozi1 wrote:

> Hi everyone. I'm just curious if anyone is dealing with or has dealt with P
> in the ear canal. I have other spots throughout the rest of my body that I
> can deal with, but it seems that the P is causing some hearing problems. I'm
> to afraid to try any meds in the ear (sideaffects unknown). Any suggestions
> would be appreciated.

First of all I would suggest you ask your pharmacist or your dermatologist.

Having said that I can tell you that my derm has said it is okay for me to use
the Dovonex or the Desowen in mine. I have used Olux Foam, but it burns. I have
had it in the ear canals so bad that I could feel and even hear it falling into
or out of the ear when in bed. The itching can become intolerable. Now I spritz
a spray of wheatgrass in each ear every day and it isn't nearly as bad. It has
been months since I have had the large pieces of skin come out of either ear and
my ear wax is normal for the first time in many years.

You might try posting the question in the forum listed below.

Whatever you decide to try, I wish you well.

--

================================================== ============================

Chuck
-τΏτ-
~
email: Lperry1940@mchsi.com
For psoriasis information go to: http://www.psoriasis.org/forum/

[brian lanning]

I treat it the way I treat most of my psoriasis. I use vaseline twice
a day. I've had it in the ear before and got creative with q-tips and
vaseline. (I know, q-tips in the ear is supposed to be bad but
everyone does it) I know that vaseline can harbor bacteria though so
I wouldn't put it too far inside. For me, this took off the scale and
kept it off.

brian

"kozi1" <tkozi1@cox.net> wrote in message news:<kx1Pb.21894$zP6.9598@okepread02>...
> Hi everyone. I'm just curious if anyone is dealing with or has dealt with P
> in the ear canal. I have other spots throughout the rest of my body that I
> can deal with, but it seems that the P is causing some hearing problems. I'm
> to afraid to try any meds in the ear (sideaffects unknown). Any suggestions
> would be appreciated.

[Charlie Wolf]

I'm not positive that we're talking about a P problem here or another
dermatitis type problem -- anyway...

The only shampoo that I can use on my hair and scalp is T-Gel shampoo
and conditioner. I also use that to clean out my ears (which has a
minor scaling issue at times) and then I also irrigate my ears every
couple of months. When I do that, I use regular ear drops which
mostly consists of softeners and lubricants so it works good in that
regard. I have also used extremely small amounts of Protopic steroid
gel in the ear after a shower too. Some others here may have an
opinion as to whether those kind of topical steroids should be used in
this regard, however I stress that I use it in extremely small
amounts.
Regards,

On Mon, 19 Jan 2004 21:47:33 -0600, "kozi1" <tkozi1@cox.net> wrote:

>Hi everyone. I'm just curious if anyone is dealing with or has dealt with P
>in the ear canal. I have other spots throughout the rest of my body that I
>can deal with, but it seems that the P is causing some hearing problems. I'm
>to afraid to try any meds in the ear (sideaffects unknown). Any suggestions
>would be appreciated.
>

[Phillip Schlueter]

Protopic is not a Steroid it is a macrolide immunosuppressant. I couldn't
find a reference to the "Gel" version, but that doesn't mean Protopic
doesn't make a "Gel".

"Charlie Wolf" <retiredUSN@noemail.com> wrote in message
news:7kgq00t26bf67u2sc9j2t42o1eo61c6j1k@4ax.com...
> I'm not positive that we're talking about a P problem here or another
> dermatitis type problem -- anyway...
>
> The only shampoo that I can use on my hair and scalp is T-Gel shampoo
> and conditioner. I also use that to clean out my ears (which has a
> minor scaling issue at times) and then I also irrigate my ears every
> couple of months. When I do that, I use regular ear drops which
> mostly consists of softeners and lubricants so it works good in that
> regard. I have also used extremely small amounts of Protopic steroid
> gel in the ear after a shower too. Some others here may have an
> opinion as to whether those kind of topical steroids should be used in
> this regard, however I stress that I use it in extremely small
> amounts.
> Regards,
>
> On Mon, 19 Jan 2004 21:47:33 -0600, "kozi1" <tkozi1@cox.net> wrote:
>
> >Hi everyone. I'm just curious if anyone is dealing with or has dealt with
P
> >in the ear canal. I have other spots throughout the rest of my body that
I
> >can deal with, but it seems that the P is causing some hearing problems.
I'm
> >to afraid to try any meds in the ear (sideaffects unknown). Any
suggestions
> >would be appreciated.
> >
>

[Charlie Wolf]

On Tue, 20 Jan 2004 15:41:40 GMT, "Phillip Schlueter"
<pschlueter@adelphia.net> wrote:

>Protopic is not a Steroid it is a macrolide immunosuppressant. I couldn't
>find a reference to the "Gel" version, but that doesn't mean Protopic
>doesn't make a "Gel".
Cool - I didn't know that. I coulda swore my derm. told me it was a
milder steroid, but I could be wrong. I guess I didn't mean "gel" -
it looks like a vaseline type base - it has exactly the same look and
consistency of Vaseline. Many of you folks posting here are much
better at this stuff than I am - I appreciate the correction.
Regards,

>
>"Charlie Wolf" <retiredUSN@noemail.com> wrote in message
>news:7kgq00t26bf67u2sc9j2t42o1eo61c6j1k@4ax.com...
>> I'm not positive that we're talking about a P problem here or another
>> dermatitis type problem -- anyway...
>>
>> The only shampoo that I can use on my hair and scalp is T-Gel shampoo
>> and conditioner. I also use that to clean out my ears (which has a
>> minor scaling issue at times) and then I also irrigate my ears every
>> couple of months. When I do that, I use regular ear drops which
>> mostly consists of softeners and lubricants so it works good in that
>> regard. I have also used extremely small amounts of Protopic steroid
>> gel in the ear after a shower too. Some others here may have an
>> opinion as to whether those kind of topical steroids should be used in
>> this regard, however I stress that I use it in extremely small
>> amounts.
>> Regards,
>>
>> On Mon, 19 Jan 2004 21:47:33 -0600, "kozi1" <tkozi1@cox.net> wrote:
>>
>> >Hi everyone. I'm just curious if anyone is dealing with or has dealt with
>P
>> >in the ear canal. I have other spots throughout the rest of my body that
>I
>> >can deal with, but it seems that the P is causing some hearing problems.
>I'm
>> >to afraid to try any meds in the ear (sideaffects unknown). Any
>suggestions
>> >would be appreciated.
>> >
>>
>

[Phillip Schlueter]

Charlie,

I tried Protopic. A Friend of mine has atopic dermatitis and he gave me
some. At almost $200 for a 60gm tube, phew, way to expensive for this
uninsured person!! Worked a litte, but nothing significant.

BTW, go to http://www.protopic.com and you can see all the info for
yourself.

PS

"Charlie Wolf" <retiredUSN@noemail.com> wrote in message
news:1vkq00hlfbmimpptdp2vco78n775q8dbc4@4ax.com...
> On Tue, 20 Jan 2004 15:41:40 GMT, "Phillip Schlueter"
> <pschlueter@adelphia.net> wrote:
>
> >Protopic is not a Steroid it is a macrolide immunosuppressant. I
couldn't
> >find a reference to the "Gel" version, but that doesn't mean Protopic
> >doesn't make a "Gel".
> Cool - I didn't know that. I coulda swore my derm. told me it was a
> milder steroid, but I could be wrong. I guess I didn't mean "gel" -
> it looks like a vaseline type base - it has exactly the same look and
> consistency of Vaseline. Many of you folks posting here are much
> better at this stuff than I am - I appreciate the correction.
> Regards,
>
> >
> >"Charlie Wolf" <retiredUSN@noemail.com> wrote in message
> >news:7kgq00t26bf67u2sc9j2t42o1eo61c6j1k@4ax.com...
> >> I'm not positive that we're talking about a P problem here or another
> >> dermatitis type problem -- anyway...
> >>
> >> The only shampoo that I can use on my hair and scalp is T-Gel shampoo
> >> and conditioner. I also use that to clean out my ears (which has a
> >> minor scaling issue at times) and then I also irrigate my ears every
> >> couple of months. When I do that, I use regular ear drops which
> >> mostly consists of softeners and lubricants so it works good in that
> >> regard. I have also used extremely small amounts of Protopic steroid
> >> gel in the ear after a shower too. Some others here may have an
> >> opinion as to whether those kind of topical steroids should be used in
> >> this regard, however I stress that I use it in extremely small
> >> amounts.
> >> Regards,
> >>
> >> On Mon, 19 Jan 2004 21:47:33 -0600, "kozi1" <tkozi1@cox.net> wrote:
> >>
> >> >Hi everyone. I'm just curious if anyone is dealing with or has dealt
with
> >P
> >> >in the ear canal. I have other spots throughout the rest of my body
that
> >I
> >> >can deal with, but it seems that the P is causing some hearing
problems.
> >I'm
> >> >to afraid to try any meds in the ear (sideaffects unknown). Any
> >suggestions
> >> >would be appreciated.
> >> >
> >>
> >
>

[Randall]

"Phillip Schlueter" <pschlueter@adelphia.net> wrote in message news:<U_bPb.2995$Fp1.1938238@news1.news.adelphia.net>...
> Protopic is not a Steroid it is a macrolide immunosuppressant.

Lets find it on that site JX uses,

http://www.rxlist.com/cgi/generic2/tacrolimus.htm
PROTOPIC (tacrolimus) Ointment contains tacrolimus, a macrolide
immunosuppressant produced by Streptomyces tsukubaensis . It is for
topical dermatologic use only. Chemically, tacrolimus is designated as
[3 S -[3 R *[ E (1 S *,3 S *,4 S *)], 4 S *,5 R *,8 S *,9 E ,12 R *,14
R *, 15 S *, 16 R *,18 S *,19 S *,26a R *]] -
5,6,8,11,12,13,14,15,16,17,18, 19,24,25,26,26a-
hexadecahydro-5,19-dihydroxy-3-
[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,
16-dimethoxy-4,10,12,18- tetramethyl-8-(2-propenyl)-15,
19-epoxy-3H-pyrido[2,1- c ]
[1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, monohydrate.
Tacrolimus has an empirical formula of C 44 H 69 NO 12 ·H 2 O and a
formula weight of 822.05. Each gram of PROTOPIC Ointment contains
(w/w) either 0.03% or 0.1% of tacrolimus in a base of mineral oil,
paraffin, propylene carbonate, white petrolatum and white wax.

How well does protopic (tacrolimus) really work?
I'll google one for your perusal later in the post.

Lets look at the soil fungi drugs again.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12459545&dopt=Abstract
Macrolides are xenobiotics, produced by soil fungi, which have
immunosuppressant properties. They will probably revolutionise the
treatment of inflammatory dermatoses. This article outlines the
context and putative mechanisms of action of this novel class of
drugs. Cyclosporin, and the structurally distinct macrolides
tacrolimus and pimecrolimus (an ascomycin derivative), modulate
immune-cell function by inhibiting calcineurin-dependent
dephosphorylation-activation of specific nuclear factors, thus
preventing transcription of pro-inflammatory cytokines. The macrolide
rapamycin (sirolimus) acts by abrogating Target of Rapamycin, a key
signalling protein that controls activation of a number of proteins
which direct progression of the cell cycle in response to
pro-inflammatory cytokines. Tacrolimus and pimecrolimus are small
enough molecules to penetrate skin and are available in topical
formulations. "Skin-specific" pimecrolimus seems not to cause systemic
immunosuppression when given orally. Neither topical tacrolimus nor
pimecrolimus are capable of producing skin atrophy. Sirolimus has
anti-angiogenic properties that may be beneficial to the treatment of
psoriasis and perhaps skin cancer.

PMID: 12459545

Answer this question. If you could put mtx on to P without going thru
the liver would you do it? Will it be as viable?
What of the effects of the P-450 cytochrome system in the p
pathways?

We may be able to put MTX right into the P patch now,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14726128&dopt=Abstract
[snip] These results suggest that liposomes containing KG may be of
value for the topical administration of MTX in the treatment of
psoriasis.

PMID: 14726128

This is one hydrogenated fat/MTX product i may consider after
the efficacy proves out. Topical hydro fats may be a great
twist in this P war. Will they prove out, though?

Some new looks at MTX, an old P workhorse,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14529545&dopt=Abstract

But what if the liver is uP stream of the P for most of us?
And in the pathways of P?

Why doesn't topical soil fungi work better topically?

http://groups.google.com/groups?q=Tacrolimus&hl=en&lr=&ie=UTF-8&selm=20010204235458.11958.00000724%40ng-fk1.aol.com&rnum=7

Could JXSterns ultimate P cocktail be right around the corner?

Finding the topicals that synergise best with the
biologicals shan't take long.

[JXStern]

On 20 Jan 2004 12:30:44 -0800, ranhub11@aol.com (Randall) wrote:
>Could JXSterns ultimate P cocktail be right around the corner?
>
>Finding the topicals that synergise best with the
>biologicals shan't take long.

Just have a couple of martinis and roll around in the dirt, it sounds
like.

J.

[Jane_Doe]

"kozi1" <tkozi1@cox.net> wrote in message news:<kx1Pb.21894$zP6.9598@okepread02>...
> Hi everyone. I'm just curious if anyone is dealing with or has dealt with P
> in the ear canal. I have other spots throughout the rest of my body that I
> can deal with, but it seems that the P is causing some hearing problems. I'm
> to afraid to try any meds in the ear (sideaffects unknown). Any suggestions
> would be appreciated.

I use a product called Diprosalic, but it's a cream type product
rather than a liquid. It comes in a few forms, useful for the scalp
and the cream is good for the sensitive areas. It's got salacylic in
it which helps with the scale.
It is steroid based, so you should get advice from a derm or doc
first.

Here's some info:
http://www.medsafe.govt.nz/Profs/Datasheet/d/Diprosalicointlot.htm

[Julie Bove]

"kozi1" <tkozi1@cox.net> wrote in message
news:kx1Pb.21894$zP6.9598@okepread02...
> Hi everyone. I'm just curious if anyone is dealing with or has dealt with
P
> in the ear canal. I have other spots throughout the rest of my body that I
> can deal with, but it seems that the P is causing some hearing problems.
I'm
> to afraid to try any meds in the ear (sideaffects unknown). Any
suggestions
> would be appreciated.

I get Seb. Derm. in my ears. I use Desonide in my ears and it clears up
very quickly.

--
Type 2
http://users.bestweb.net/~jbove/

[Miss Grunge]

I use Diprosone ointment applied with a cottonbud. Very successful and
gives great relief :-)
Miss G


"> "kozi1" <tkozi1@cox.net> wrote in message
> news:kx1Pb.21894$zP6.9598@okepread02...
> > Hi everyone. I'm just curious if anyone is dealing with or has dealt
with
> P
> > in the ear canal. I have other spots throughout the rest of my body that
I
> > can deal with, but it seems that the P is causing some hearing problems.
> I'm
> > to afraid to try any meds in the ear (sideaffects unknown). Any
> suggestions
> > would be appreciated.
>