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Old 05-05-2007, 03:28 AM   #1
Roman Bystrianyk
 
Default Cholesterol and prostate cancer

http://www.healthsentinel.com/news.p...st_item&id=689

"Cholesterol feeds prostate cancer", BBC News, March 18, 2005,
Link: http://news.bbc.co.uk/2/hi/health/4359117.stm

High cholesterol levels accelerate the growth of prostate tumours,
research has found.

A team from Boston's Children Hospital also found that
cholesterol-lowering statin drugs may inhibit prostate cancer growth.

The findings may help explain why prostate cancer is more common in the
West, where diets tend to be high in cholesterol.

Details are published in the Journal of Clinical Investigation.

Rates of prostate cancer in rural parts of China and Japan, where low
fat diets are the norm, are up to 90% less than in the West.

Yet when Eastern men migrate to the West their chances of being
diagnosed with prostate cancer increase.

This has led doctors to suspect that environmental factors - such as
diet - may play a significant role in the development of the disease.

Mice experiments

The Boston team injected human prostate cancer cells into mice and
watched them grow.

When the animals were fed high cholesterol diets, cholesterol was found
to accumulate in the outer membranes of tumour cells.

This appeared to alter chemical signalling patterns within the cells.

As a result, they resisted signals telling them to commit suicide and
instead continued to proliferate in the uncontrolled fashion seen in
cancer.

The increased cholesterol levels did not trigger new cancers in the
mice.

But six weeks after the tumour cells were injected, mice on the
high-cholesterol diets had twice as many tumours as animals on ordinary
diets.

Their tumours were also much larger in size.

When the cells were exposed to the cholesterol-lowering drug
simvastatin, cell death increased and tumours stopped proliferating.

But replenishing cell membranes with cholesterol caused the cancer to
run out of control again.

Lead researcher Dr Michael Freeman said: "Our study opens up a new
paradigm in thinking about how cancer might be controlled
pharmacologically by manipulating cholesterol.

"Our data support the notion that cholesterol-lowering drugs - which
are widely used and fairly safe - might be effective in prevention of
prostate cancer, or as an adjunctive therapy."

Chris Hiley, of the UK Prostate Cancer Charity, said: "This research is
clearly at an early stage, as it was accomplished in mouse cells, not
men, but it's heartening to see a plausible connection made between
processes inside cells and the Westernised high fat diet that seem to
increase the risk of prostate cancer occurring.

"The results do open up thinking about new drug therapies.

"But there is also a low tech option any man could attempt today.

"Adopt a healthy low cholesterol diet and active lifestyle.

"Cut down on saturated fats, reduce the total amount of fat eaten but
eat oily fish, and eat a high fibre diet - with porridge oats, and
plenty of fresh fruit and vegetables."

Every year 27,000 men are diagnosed with prostate cancer and 10,000 men
die from it.
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Old 05-05-2007, 03:28 AM   #2
montygram
 
Default Re: Cholesterol feeds prostate cancer

Wow - what a ridiculous experiment. Why not just take the serum
cholesterol levels of men with prostate cancer, then see if progression
is related to the cholesterol level? Even then, what should be
measured is the oxysterol content of the serum, meaning oxidized
cholesterol. The only thing I'd like to know is if the "researchers"
bothered to determine whether the cholesterol they fed the tumors had
high oxysterol contents. This seems to be the case, because the statin
drug lowers inflammation, and cholesterol does too, if it's not
oxidized. If it's oxidized it will create inflammation. It's amazing
how so many "scientists" are ignorant of recent research.
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Old 05-05-2007, 03:28 AM   #3
Cubit
 
Default Re: Cholesterol feeds prostate cancer

How does cholesterol become oxidized?

Does this mean that those who eat cholesterol need to avoid rancid fats?


"montygram" <nazztrader@lycos.com> wrote in message
news:1111174635.068267.40730@f14g2000cwb.googlegro ups.com...
> Wow - what a ridiculous experiment. Why not just take the serum
> cholesterol levels of men with prostate cancer, then see if progression
> is related to the cholesterol level? Even then, what should be
> measured is the oxysterol content of the serum, meaning oxidized
> cholesterol. The only thing I'd like to know is if the "researchers"
> bothered to determine whether the cholesterol they fed the tumors had
> high oxysterol contents. This seems to be the case, because the statin
> drug lowers inflammation, and cholesterol does too, if it's not
> oxidized. If it's oxidized it will create inflammation. It's amazing
> how so many "scientists" are ignorant of recent research.
>
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Old 05-05-2007, 03:29 AM   #4
montygram
 
Default Re: Cholesterol feeds prostate cancer

First off, the worst dietary sources are powdered dairy and foods
cooked while exposed to air. A recent expiment showed that steaming
salmon was the worst cooking method. Fatty acid researcher Mary Enig
also has warned about homogenization. Then there's fat that's gone
rancid, which should be avoided entirely (I skim the yellowed sides off
sticks of butter for this reason). Remember that cholesterol is a
protein carrier of fat.

Also, if you eat cholesterol and also polyunsaturated fatty acids (and
some forms of monounsaturated fatty acids, like canola, which really
depletes antioxidant resources), the cholesterol can become oxidized
inside your body. Eating berries, dark chocolate, etc. help to some
degree. I boil eggs, which is okay because the cholesterol can't
become oxidized unless oxygen is present. The presence of iron can
speed up the process too (and copper, in particular ways). Even though
the evidence is overwhelming, and even a spokesman for the AHA has
recently pointed out that only oxidized cholesterol is a problem in any
physiologically normal state, the word has not reached most of the
"talking heads" in the mainstream media.
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Old 05-05-2007, 03:29 AM   #5
Jeff
 
Default Re: Cholesterol feeds prostate cancer

"Roman Bystrianyk" <rbystrianyk@gmail.com> wrote in message
news:1111156508.031954.269370@l41g2000cwc.googlegr oups.com.

This study supports the contention that if you watch your diet, you will be
healthier.

I think the conclusion that cholesterol lowering drugs will help prevent
prostate cancer or decrease its spread is premature.

Cholesterol is used in the synthesis of testoerone and sex hormones (both
male and female). This may also be related to the results.

Jeff
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Old 05-05-2007, 03:29 AM   #6
montygram
 
Default Re: Cholesterol feeds prostate cancer

Yes, watch the food instead of eat it - that is supported by the
studies on calorie restriction.
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Old 05-05-2007, 03:31 AM   #7
Alf Christophersen
 
Default Re: Cholesterol feeds prostate cancer

On 18 Mar 2005 12:17:15 -0800, "montygram" <nazztrader@lycos.com>
wrote:

>some forms of monounsaturated fatty acids, like canola, which really
>depletes antioxidant resources), the cholesterol can become oxidized


Interesting, so the label Canola oil is a switch that turn on C18:1
omega-9 toxic while label olive oil turn this effect off. Very
interesting.

Canola oil do not contain C20:1 omega-9
Could you repeat that??
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Old 05-05-2007, 03:31 AM   #8
MattLB
 
Default Re: Cholesterol feeds prostate cancer

montygram wrote:
>
> First off, the worst dietary sources are powdered dairy and foods
> cooked while exposed to air. A recent expiment showed that steaming
> salmon was the worst cooking method.


Yet steaming exposes it to the air less than other methods.

I don't know whether you read the actual paper, but the lipid oxidation
was unchanged and only cholesterol oxidation increased. Since the
steaming was carried on for far longer than the other cooking methods it
was probably due to duration.

> Fatty acid researcher Mary Enig
> also has warned about homogenization. Then there's fat that's gone
> rancid, which should be avoided entirely (I skim the yellowed sides off
> sticks of butter for this reason). Remember that cholesterol is a
> protein carrier of fat.


What's that supposed to mean? Cholesterol isn't protein and it isn't a
carrier of fat.

> Also, if you eat cholesterol and also polyunsaturated fatty acids (and
> some forms of monounsaturated fatty acids, like canola, which really
> depletes antioxidant resources), the cholesterol can become oxidized
> inside your body. Eating berries, dark chocolate, etc. help to some
> degree. I boil eggs, which is okay because the cholesterol can't
> become oxidized unless oxygen is present.


Oxygen isn't a requirement for oxidation. Boiling is better mostly
because the temperature is limited, athough the fact that hot oil and
high surface area aren't involved makes a big difference.

> The presence of iron can
> speed up the process too (and copper, in particular ways).


Iron and copper can oxidise biomolecules directly with the presence of
oxygen, although they will also generate oxygen radicals and thence
hydroxyl radicals.

MattLB
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Old 05-05-2007, 03:31 AM   #9
Alf Christophersen
 
Default Re: Cholesterol feeds prostate cancer

On Mon, 21 Mar 2005 18:26:46 +0000, MattLB <mattlb2@FAKEBITlycos.com>
wrote:

>> sticks of butter for this reason). Remember that cholesterol is a
>> protein carrier of fat.

>
>What's that supposed to mean? Cholesterol isn't protein and it isn't a
>carrier of fat.


right. Cholesterol is a fat. By being a carrier of fatty acids.
But in HDL and LDL it is helped by lipid binding proteins, that is,
proteins binding also cholesterol esters.

But unesterified cholesterol could be questioned whether being fat or
not.
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Old 05-05-2007, 04:19 AM   #10
Robert Cohen
 
Default Re: Cholesterol feeds prostate cancer

Atlanta WSB Channel 2 tv's Doctor Martin yesterday/recently:

Statins are two-fers

1. anti-cholesterol
2. anti-prostate cancer, something like a 50 percent reduction in
prostate c

Layperson comment: Too good to be true, though please pass me some more
of that 20 mg Lovastatin meanwhile & until it gets knocked down with
bad side-effects--ya wanna bet?
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Old 05-05-2007, 04:19 AM   #11
none
 
Default Re: Cholesterol feeds prostate cancer

Robert Cohen wrote:
> Atlanta WSB Channel 2 tv's Doctor Martin yesterday/recently:
>
> Statins are two-fers
>
> 1. anti-cholesterol
> 2. anti-prostate cancer, something like a 50 percent reduction in
> prostate c
>
> Layperson comment: Too good to be true, though please pass me some more
> of that 20 mg Lovastatin meanwhile & until it gets knocked down with
> bad side-effects--ya wanna bet?
>

Check the latest issue of Skeptic Magazine for an article with a rather
dissenting and interesting view on cholesterol. I'm looking forward to
the reactions to that article in the next issue. Looks like statistics
have been abused in a way that would even make the quacks blush, either
by the writer of the article or a number of researchers. One example: it
has been recommended to lower cholesterol levels in children. The writer
of the article however has a graph with cholesterol levels in children
against childmortality. The graph clearly shows that low cholesterol is
correlated with high mortality! The writers admits the graph is silly
and does not prove any connection, but then argues that many other, less
silly graphs involving the effects of cholesterol are just as wrong.
Well worth reading.
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Old 05-05-2007, 04:25 AM   #12
Robert Cohen
 
Default Re: Cholesterol feeds prostate cancer

re: SKEPTICAL ENQUIRER article about cholesterol

I went to website, but couldn't find the cholesterol article that's
referred.

B-T-W: Years ago I subscribed (by snail mail) to the magazine for about
$16 a year
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Junior Member
 
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