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Old 05-11-2007, 10:20 PM   #1
Default retinopathy / Macular degeneration / cause ? / treatment ?

hemorrheological factors may play a role in the development of hypertensive and
diabetic retinopathy

Orv Hetil. 2001 May 20;142(20):1045-8. Related Articles, Links

[Hemorheologic factors in hypertensive and diabetic retinopathy]

[Article in Hungarian]

Vekasi J, Marton Z, Kesmarky G, Cser A, Russai R, Kovacs B.

Pecsi Tudomanyegyetem, Altalanos Orvostudomanyi Kar, Szemeszeti Klinika.

Hemorheological factors play an important role in the pathogenesis of different
cardiovascular diseases. In the present study the fundus picture and
hemorheological parameters (plasma and whole blood viscosity *WBV* by capillary
viscosimetry; fibrinogen level; red blood cell aggregation by Myrenne and LORCA
aggregometers) of 33 hypertensive patients (23 females, 10 males; mean age: 55
years) and 30 diabetic patients (14 females, 16 males; mean age: 57 years) and
healthy controls were examined. The fundus pictures showed different forms of
retinopathy in both groups. All the measured hemorheological parameters of the
examined patients were in the pathological range and were significantly higher
than in healthy controls. In the group of hypertensive patients hematocrit (p <
0.05), plasma fibrinogen (p < 0.01), plasma viscosity (p < 0.01) and whole
blood viscosity (p < 0.01) showed a significant increase. The hemorrheological
factors showed a parallel deterioration with the severity of hypertension
(measured BP values) and of fundus picture, namely their values were
significantly (p < 0.01) higher in patients with stage III fundus picture (WBV
at 90 1/s: 6.02 mPas), than stage I hypertension (WBV at 90 1/s: 4.51 mPas). In
the diabetic group hematocrit (p < 0.01), plasma fibrinogen (p < 0.001), plasma
viscosity (p < 0.01), "WBV" (p < 0.001), red blood cell aggregation (p < 0.05)
showed a significant increase comparing to healthy controls. These results show
that there is a correlation between hemorrheological parameters and fundus
picture in hypertensive and diabetic patients, and this suggests that
hemorrheological factors may play a role in the development of hypertensive and
diabetic retinopathy.

PMID: 11407065 [PubMed - indexed for MEDLINE]


Diabetes Res. 1986 Feb;3(2):67-70. Related Articles, Links

Increased blood viscosity in diabetic proliferative retinopathy.

Lowe GD, Ghafour IM, Belch JJ, Forbes CD, Foulds WS, MacCuish AC.

Blood rheology and haemostasis were assessed in 18 diabetics with proliferative
retinopathy and in 18 diabetics without proliferative retinopathy, matched for
age, sex, smoking habit and type, duration and treatment of diabetes.
Proliferative retinopathy was associated with significantly higher levels of
blood viscosity at high and low shear rates, which were related to higher
levels of plasma viscosity and fibrinogen. Blood urea, glucose, glycosylated
haemoglobin and white cell count were also significantly higher, whereas
haematocrit, red cell deformability and several other haematological and
biochemical variables did not differ significantly in the 2 groups. In view of
these findings, and of our recent demonstration that increased blood viscosity
also exists in those patients with retinal vein occlusion who develop a similar
proliferative retinopathy, we suggest that hyperviscosity may contribute to
retinal ischaemia and hence proliferative retinopathy.

PMID: 3698481 [PubMed - indexed for MEDLINE]


Since ischaemic / lack of blood flow injury seems to be INDUCED by the .. iron
... from .. the blood spilled .. ie: evidenced by the alleviation by iron
chelators .. then one might think elimination / removal of iron IN the eye
might facilitate .. recovery .. ?


Of the 10 compounds known to chelate iron, only pyrrolidine dithiocarbamate,
TEMPOL and Trolox decreased activity.


As in macular degeneration .. ?


As in phytic acid SHOWN / known to ELIMINATE .. neovascularization /
angiogenesis.. the HALLMARK of .. macular degeneration.


Coincidence .. ?

Not .. likely ..

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